Christianity reached Spoleto quite early, as testified to by the presence of many local martyrs, still venerated today, and by documents certifying the presence of the bishop see since the 4th century. Many religious buildings in Spoleto have very old origins and often underwent renovations, especially during the Romanesque and Renaissance periods, with the arrival of such artists as Filippo Lippi or Pintoricchio.
The renovation or construction of new churches during the 17th and 18th centuries often occurred thanks to outstanding bishops and local noblemen, who helped establish strict connections with Rome and the great artists orbiting around the Holy See.